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Prof. Wanjun Chen: Tregs——免疫治疗道路上不可或缺的靶点

Published at: 2015年第1卷第S1期

闫梦梦
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2017年11月10日-11日,由中国工程院医药卫生学部及南京医科大学主办,AME出版社和江苏省免疫协会协办,南京医科大学附属江宁医院、江苏省转化医学研究院、南京医科大学转化医学研究院及江苏省免疫学会转化医学专业委员会承办的“2017 医学免疫与临床应用高峰论坛”在宁顺利召开。 来自美国国立卫生研究院的的Prof. Wanjun Chen在会上发表了题为“Regulatory T cells in immune tolerance and immunotherapy”的精彩演讲(图1)。会议间歇,小编对Prof. Chen进行了专访。

图1. Prof. Wanjun Chen

自1995年,日本学者Sakaguchi等发现并命名了调节性T细胞(Tregs)以来,越来越多的专家开始关注Tregs在调控人体免疫系统中所起的关键作用。Prof. Chen认为虽然目前大家已经对Tregs 的发育过程以及主要功能方面有了一定的了解,但是我们还是面临着一些更加艰巨的挑战。比如,如何才能做到将研究成果运用到临床上某一种特定免疫性疾病的治疗呢?虽然目前未解决的难题还有很多,但是Prof. Chen认为Tregs用于免疫系统疾病治疗的前景是非常可观的,Tregs未来将会在免疫系统疾病治疗中扮演一个不可或缺的角色。

Prof. Chen的研究主要集中在TGFβ调节T细胞免疫耐受的机制。Prof. Chen首次发现了TGF-beta 可促使初始T细胞中FoxP3 基因的表达并将其转变为调节型T细胞(induced regular T cells, iTreg)。Prof. Chen表示在接下来几年的主要研究工作就是探讨如何将这项研究应用于临床,造福患者。

如何才能成为一名合格的研究工作人员呢?Prof. Chen谈到,每一个人的能力不同,背景不同,耐心程度不同以及衡量标准等也不同。只有真正对科研感兴趣并且足够有耐心的人,才能融入“reading, reading and more reading; thinking, thinking and more thinking”的科研氛围。

更多精彩内容,请戳下方视频。

采访问题

1. In your opinion, what is the current status of the regulatory T cells in immunotherapy? Any challenges we are facing?

2. What do you think about its future?

3. Could you share your recent research with us?

4. How did you get involved in the field of Immunology?

5. How to be a qualified Investigator in your view?

人物聚焦:Prof. Wanjun Chen

Wanjun Chen, Professor

Senior Investigator

Chief, Mucosal Immunology Section

Prof. Chen is an internationally recognized immunologist. His research focuses on elucidating mechanisms of T-cell immunity and tolerance and manipulating T-cell immunity versus tolerance in animal models to understand the pathogenesis of and develop immunotherapy for autoimmunity, cancer and infectious diseases. He is the first in the world who discovered that TGF-beta induces Foxp3 gene in naïve CD4+ T cells and converts them into iTregs. The papers describing this finding has been cited for more than 4000 times. He has published more than 100 peer-reviewed articles in internationally prestigious journals including Nature, Nature Medicine, Nature Immunology, Immunity, etc.

图2. 采访花絮


采写编辑:闫梦梦 AME Publishing Company

视频剪辑:麦雪芳 AME Publishing Company

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