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Daniel Candotti教授:从新视角看待古老病毒

Published at: 2015年第1卷第S1期

胡舒欣 , 李肖梅
关键词:

编者按:7月13日至14日,广东省血液安全培训班在广州圆满召开。会议集结了国内外多位著名的血液安全领域、流行病研究专家。来自法国输血研究院的Daniel Candotti教授作为本次会议的特邀讲者,远道而来,在会议上就“HBV transfusion transmission despite the use of highly sensitive HBV NAT”一题进行了精彩的演讲。Candotti教授也是AME旗下杂志Annals of Blood的编委和作者,他从事输血安全领域已有17年,出版了80多篇科学论文,在血液安全和输血病毒性感染的科学研究领域拥有丰富经验,我们有幸邀请到他进一步分享个人的研究进展,以及对于领域内一些热点问题的看法。

人物聚焦

Daniel Candotti, PhD: National Institute of Blood Transfusion, Department of Blood transmissible Agents, National Reference Centre for B & C Hepatitis and HIV in Transfusion, Paris, France

Prof. Candotti is a Senior Research Scientist and Deputy Head of the Department of Blood Transmissible Agents, National Institute of Blood Transfusion (INTS), Paris, France. He received his PhD degree in Virology in the Pierre & Marie Curie University (Paris VI). Prof. Candotti acquired an extensive experience in molecular virology and blood-borne virus infections working for the AIDS Research National Agency (ANRS), Pitié-Salpêtrière Hospital, and in the Division of TransfusionMedicine, University of Cambridge, and National Health Service Blood & Transplant, UK. Prof. Candotti is engaged in scientific researches in blood safety and transfusion-transmitted viral infections. His research work is essentially focused on molecular epidemiology and molecular mechanisms of host-pathogens interaction in persistent viral infections, mainly HBV, in blood donors. 

采访问题:

Q1

First, would you please give us a brief introduction to yourself, such as your specialities and interests?

Q2

HBV has long been studied in the medical field. What issues/studies are hot on HBV in field of blood transfusion?

Q3

You did an excellent presentation yesterday. Could you summarize some main points of your presentation to us?

Q4

More and more items are included in the screening of blood donors, for example, HTLV, WNV and Zika in America. Do you think there will be more pathogens included for blood donor screening?

Q5

You’ve served in blood transfusion safety field for almost 20 years. Based on your rich experience, do you have particular words to our readership or those who are going to study in this field? 

本次会议上,Daniel Candotti教授(图1)探讨了HBV(乙型肝炎病毒)在输血安全领域的研究。 很多人认为,HBV是一个古老的病毒,相关疫苗和治疗研究也很多。但Candotti教授认为,当我们更深入地研究后,会发现我们对其认识还远远不够。HBV感染是一个终身问题,无法根除。很多疫苗却只能预防疾病,不能有效解决感染后的问题。Candotti教授还谈及了另一个问题:尽管目前输血界已有高灵敏的检测方法,如核酸检测技术(NAT),但仍有部分病毒无法被标记,人们依然有感染的风险。

图1. Prof. Daniel Candotti在发表演讲

Candotti教授从事输血安全领域已有17年,出版了80多篇科学论文,在血液安全和输血病毒性感染的科学研究领域拥有丰富经验。他也是AME旗下杂志Annals of Blood的编委和作者,会前与编辑已建立良好的友谊。借着本次会议的机会,我们有幸邀请到他进一步分享个人的研究进展,以及对于领域内一些热点问题的看法。

谈到未来血液病毒筛查是否会增加新病原体的筛查,Candotti教授持谨慎态度。他认为这取决于未来我们要面对的紧急情况。很多病毒都是季节性问题,如前几年爆发的寨卡和埃博拉,因此在病毒爆发短时期内需要增加额外检测。不过他认为短期内不会出现较紧急情况。

图2. 采访编辑李肖梅,Daniel Candotti教授(左二)与AOB编辑钟珊珊

最后, Candotti教授分享了他的研究感悟。他认为,研究病毒和消灭病毒仍是路漫漫其修远,HBV就是很好的例子。他建议输血领域的研究人员和医务人员要时刻准备好使用新科技,如深度测序、下一代测序技术等。此外,还要关注可能导致新型病毒感染出现的潜在问题,如人口和气候变化。更重要的是,学会用不同的视角看待问题,尤其是新视角。他举例说研究人类传染病,也要考虑动物传染病,因为两者界限并不大。还要努力拓宽知识面,而不是局限在输血领域。

更多精彩内容的分享,欢迎观看视频。

采访编辑:李肖梅,AME Publishing Company

写作编辑:胡舒欣,AME Publishing Company

视频编辑:陈国豪,AME Publishing Company

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