专题编辑

《基因组技术的资料分析》专题编辑

Published at: 2014年第1卷第17期

关键词:

项目负责人:

庄曜宇  Eric Y. Chuang

Professor, Department of Electrical Engineering, National Taiwan University

教授,国立台湾大学电机工程学系、国立台湾大学生医电资所、国立台湾大学生命科学系、国立台湾大学流行病学所、国立台湾大学动物所;主持人,国立台湾大学基因体医学研究中心-基因体医学组-生物统计暨生物资讯核心实验室;主任,国立台湾大学永龄生医工程中心。

2009-2012 NCI Radiation Research Program 专案负责人 (http://rrp.cancer.gov/aboutRRP/bios/chuang_eric.htm)

《癌症转化研究》Translational Cancer Research主編,杂志链接:www.thetcr.org

Lab. Homepage:

Microarray Laboratory (生物晶片实验室)

National Center of Excellenc for Clinical Trial and Research (台大医院国家级卓越临床试验与研究中心转译实验室三)

主要研究领域:

生物芯片 (Biochip), 生物资讯 (Bioinformatics), 癌症生物学(Cancer Biology)

代表性著作 Selected Publication

  1. Chen HI, Hsu FH, Jiang Y, et al., “A probe-density-based analysis method for array CGH data: simulation, normalization and centralization,” Bioinformatics, 24(16), 1749-56, 2008

  2. M.-H. Tsai, J.A. Cook, G.V.R. Chandramouli, W. DeGraff, H. Yan, S. Zhao, C.N. Coleman, J.B. Mitchell, E.Y. Chuang, “Gene Expression Profiling of Breast, Prostate, and Glioma Cells Following Single Versus Fractionated Doses of Radiation,” Cancer Res., 67, 3845-3852, 2007

  3. W. Zhao*, E.Y. Chuang*, M. Mishra, R. Awwad, K. Bisht, L. Sun, P. Nguyen, J.D. Pennington, T.J. Wang, C.M. Bradbury, L. Huang, Z. Chen, G. Bar-Sela, M.E. Robbins, D. Gius, “Distinct effects of ionizing radiation on in vivo murine kidney and brain normal tissue gene expression,” Clin Cancer Res, 12, 3823-3830, 2006

  4. E. Y. Chuang, X. Chen, M.-H. Tsai, H. Yan, C.-Y. Li, J. B. Mitchell, H. Nagasawa, P. F. Wilson, Y. Peng, J. S. Bedford, and J. B. Little, “Abnormal Gene Expression Profiles in Unaffected Parents of Patients with Hereditary Type Retinoblastoma,”Cancer Res., 66, 3428-33, 2006

蔡孟勳  Mong-Hsun Tsai

Associate Professor, Institute of Biotechnology, National Taiwan University

副教授,国立台湾大学生物科技研究所;共同主持人,国立台湾大学基因体医学研究中心-基因体医学组-生物统计暨生物资讯核心实验室。

主要研究领域:

生物晶片(Biochip), 細胞生物(Cell Biology), 生物资讯 (Bioinformatics) , 放射生物学(Radiation Biology)

代表性著作 Selected Publication

  1. Tzu-Pin Lu, Liang-Chuan Lai, Be-i Lin, Li-Han Chen, Tzuhung Hsiao, Howard L. Liber, John A. Cook, James B. Mitchell, Mong-Hsun Tsai* AND Eric Y. Chuang, “Distinct signaling pathways after higher or lower doses of radiation in three closely related human lymphoblast cell lines,” Int. J. Radiation Oncology Biol. Phys., 76, No. 1, pp. 212–219, 2010. *Co-coresponding

  2. Tzu-Pin Lu, Mong-Hsun Tsai*, Jang-Ming Lee, Chung-Ping Hsu, Pei-Chun Chen, Chung-Wu Lin,Jin-Yuan Shih, Pan-Chyr Yang, Chuhsing Kate Hsiao, Liang-Chuan Lai, and Eric Y. Chuang., “Identification of a Novel Biomarker, SEMA5A, for Non–Small Cell Lung Carcinoma in Nonsmoking Women, ” Cancer Epidemiology, Biomarkers & Prevention, 19:2590-2597,2010. *Co-first

  3. Pei-Chun Chen, Yen-Ching Chen, Liang-Chuan Lai, Mong-Hsun Tsai*,Shin-Kuang Chen, Pei-Wen Yang, Yung-Chie Lee, Chuhsing K. Hsiao, Jang-Ming Lee ,Eric Y. Chuang. Use of Germline Polymorphisms in Predicting Concurrent Chemoradiotherapy Response in Esophageal Cancer. International Journal of Radiation Oncology*Biology*Physics. 82(5): 1996-2003, 2012.*Co-first

  4. Wu CH, Tsai MH*, Ho CC, Chen CY, Lee HS., De novo transcriptome sequencing of axolotl blastema for identification of differentially expressed genes during limb regeneration, BMC Genomics., 14:434, 2013. *Co-first author

赖亮全 Liang-Chuan Lai

Associate Professor, Department of Physiology, College of Medicine, National Taiwan University

副教授,国立台湾大学医学院生理学研究所;共同主持人,国立台湾大学基因体医学研究中心-基因体医学组-生物统计暨生物资讯核心实验室

主要研究领域:

癌症生物学 (Cancer Biology), 生物资讯 (Bioinformatics)

代表性著作 Selected Publication

  1. T. P. Lu, K. T. Chen, M. H. Tsai, K. T. Kuo, C. K. Hsiao, L. C. Lai, and E. Y. Chuang. Identification of Genes with Consistent Methylation Levels across Different Human Tissues. Sci Rep. 2014. 4:4351.

  2. Y. J. Liu, Y. F. Lin, Y. F. Chen, E. C. Luo, Y. P. Sher, M. H. Tsai, E. Y. Chuang, and L. C. Lai. MicroRNA-449a Enhances Radiosensitivity in CL1-0 Lung Adenocarcinoma Cells. PLoS One. 2013. Apr. 8:e62383.

  3.  L. C. Lai, Y. Y. Su, K. C. Chen, M. H. Tsai, Y. P. Sher, T. P. Lu, C. Y. Lee, and E. Y. Chuang. Down-Regulation of NDRG1 Promotes Migration of Cancer Cells during Reoxygenation. PLoS One. 2011. Aug. 6:e24375.

  4. T. P. Lu, M. H. Tsai, J. M. Lee, C. P. Hsu, P. C. Chen, C. W. Lin, J. Y. Shih, P. C. Yang, C. K. Hsiao,L. C. Lai, and E. Y. Chuang. Identification of a novel biomarker, SEMA5A, for non-small cell lung carcinoma in nonsmoking women. Cancer Epidemiology, Biomarkers & Prevention. 2010. Oct. 19:2590-7.

项目成员:

郭育伦;邱钰乔;李建乐;萧人豪;谢嘉珊;王亮博
 

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