AME国际病例

AME国际病例103 | CPT-11化疗挽救非典型硬化性上皮样纤维肉瘤急症1例

Published at: 2015年第1卷第58期

Chun-hua Pan 1 , Xi-qun Han 2 , Jian-sheng Li 3
1 Department of Medical Oncology, Affiliated Tumor Hospital of Guangzhou Medical College, Guangzhou 510095, China
2 Department of Pathology, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, China
3 Department of Image, Affiliated Tumor Hospital of Guangzhou Medical College, Guangzhou 510095, China

摘要

硬化性上皮样纤维肉瘤(sclerosing epithelioid fibrosarcoma,SEF)是一种罕见的、定义不清的纤维肉瘤亚型,但总体上对化疗不敏感,容易进展,预后较差。本文报道了盐酸伊立替康(CPT-11)化疗挽救1例非典型SEF急症患者的神奇作用,该患者在接受多种治疗方法后病情复发。给予该患者小剂量CPT-11后,肉眼观察患者体表肿物(颈部淋巴结)尺寸在5 d内逐渐减小。X线和CT影像证实肿瘤尺寸显著减小。CPT-11对于该侵袭性肉瘤的治疗是有价值的。对于肉瘤压迫引起的急症,给予可耐受的、小剂量拓扑异构酶Ⅰ抑制剂可能是一种有益的选择。

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